35K20 Initial-boundary value problems for second-order parabolic equations
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Keywords
- cancer cell invasion (2)
- degenerate diffusion (2)
- global existence (2)
- haptotaxis (2)
- parabolic system (2)
- weak solution (2)
- Methode der Fundamentallösungen (1)
- Poroelastizität (1)
- Theorie schwacher Lösungen (1)
- go-or-grow dichotomy (1)
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We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network
under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features
two interacting cell populations with their mutual transitions and involves tissue-dependent degenerate diffusion and
haptotaxis for the moving subpopulation. The proliferating cells and the tissue evolution are characterized by way of ODEs
for the respective densities. We prove the global existence of weak solutions and illustrate the model behaviour by
numerical simulations in a two-dimensional setting.
We propose and study a strongly coupled PDE-ODE system with tissue-dependent degenerate diffusion and haptotaxis that can serve as a model prototype for cancer cell invasion through the
extracellular matrix. We prove the global existence of weak solutions and illustrate the model behaviour by numerical simulations for a two-dimensional setting.
This report gives an insight into basics of stress field simulations for geothermal reservoirs.
The quasistatic equations of poroelasticity are deduced from constitutive equations, balance
of mass and balance of momentum. Existence and uniqueness of a weak solution is shown.
In order of to find an approximate solution numerically, usage of the so–called method of
fundamental solutions is a promising way. The idea of this method as well as a sketch of
how convergence may be proven are given.