Frank Lenzen

• This essay discusses the multileaf collimator leaf sequencing problem, which occurs in every treatment planning in radiation therapy. The problem is to find a good realization in terms of a leaf sequence in the multileaf collimator such that the time needed to deliver the given dose profile is minimized. A mathematical model using an integer programming formulation has been developed. Additionally, a heuristic, based on existing algorithms and an integer programming formulation, has been developed to enhance the quality of the solutions. Comparing the results to those provided by other algorithms, a significant improvement can be observed.