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A stochastic multiscale model for acid mediated cancer invasion

  • Cancer research is not only a fast growing field involving many branches of science, but also an intricate and diversified field rife with anomalies. One such anomaly is the consistent reliance of cancer cells on glucose metabolism for energy production even in a normoxic environment. Glycolysis is an inefficient pathway for energy production and normally is used during hypoxic conditions. Since cancer cells have a high demand for energy (e.g. for proliferation) it is somehow paradoxical for them to rely on such a mechanism. An emerging conjecture aiming to explain this behavior is that cancer cells preserve this aerobic glycolytic phenotype for its use in invasion and metastasis. We follow this hypothesis and propose a new model for cancer invasion, depending on the dynamics of extra- and intracellular protons, by building upon the existing ones. We incorporate random perturbations in the intracellular proton dynamics to account for uncertainties affecting the cellular machinery. Finally, we address the well-posedness of our setting and use numerical simulations to illustrate the model predictions.

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Metadaten
Verfasserangaben:Sandesh Hiremath, Christina Surulescu
URN (Permalink):urn:nbn:de:hbz:386-kluedo-38192
Dokumentart:Preprint
Sprache der Veröffentlichung:Englisch
Veröffentlichungsdatum (online):30.06.2014
Jahr der Veröffentlichung:2014
Veröffentlichende Institution:Technische Universität Kaiserslautern
Datum der Publikation (Server):02.07.2014
Freies Schlagwort / Tag:multiscale model, acid-mediated tumor invasion, reaction-diffusion equations, random differential equations
Seitenzahl:36
Fachbereiche / Organisatorische Einheiten:Fachbereich Mathematik
DDC-Sachgruppen:5 Naturwissenschaften und Mathematik / 510 Mathematik
Lizenz (Deutsch):Standard gemäß KLUEDO-Leitlinien vom 10.09.2012