Mohamed Hassan, Sara-Cathrin Krieg, Cedric Ndefo Nde, Jessica Roos, Thorsten J. Maier, Eman A. El Rady, Mohamed A. Raslan, Kamal U. Sadek, Georg Manolikakes

• A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one-pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodology offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non-natural NFA derivatives.