Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters
- A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alcohol unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an additional stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.
Author: | Sara-Cathrin Krieg, Jennifer Grimmer, Philipp KramerORCiD, Michael BolteORCiD, Harald Kelm, Georg ManolikakesORCiD |
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URN: | urn:nbn:de:hbz:386-kluedo-80434 |
DOI: | https://doi.org/10.1002/anie.202109752 |
ISSN: | 1521-3773 |
Parent Title (English): | Angewandte Chemie International Edition |
Publisher: | Wiley |
Document Type: | Article |
Language of publication: | English |
Date of Publication (online): | 2024/04/16 |
Year of first Publication: | 2021 |
Publishing Institution: | Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau |
Date of the Publication (Server): | 2024/04/16 |
Issue: | 60/44 |
Page Number: | 5 |
First Page: | 23667 |
Last Page: | 23671 |
Source: | https://onlinelibrary.wiley.com/doi/10.1002/anie.202109752 |
Faculties / Organisational entities: | Kaiserslautern - Fachbereich Chemie |
DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 540 Chemie |
Collections: | Open-Access-Publikationsfonds |
Licence (German): | Zweitveröffentlichung |