Heme Oxygenase-1 and Its Role in Colorectal Cancer
- Heme oxygenase-1 (HO-1) is an enzyme located at the endoplasmic reticulum, which is responsible for the degradation of cellular heme into ferrous iron, carbon monoxide and biliverdin-IXa. In addition to this main function, the enzyme is involved in many other homeostatic, toxic and cancer-related mechanisms. In this review, we first summarize the importance of HO-1 in physiology and pathophysiology with a focus on the digestive system. We then detail its structure and function, followed by a section on the regulatory mechanisms that control HO-1 expression and activity. Moreover, HO-2 as important further HO isoform is discussed, highlighting the similarities and differences with regard to HO-1. Subsequently, we describe the direct and indirect cytoprotective functions of HO-1 and its breakdown products carbon monoxide and biliverdin-IXa, but also highlight possible pro-inflammatory effects. Finally, we address the role of HO-1 in cancer with a particular focus on colorectal cancer. Here, relevant pathways and mechanisms are presented, through which HO-1 impacts tumor induction and tumor progression. These include oxidative stress and DNA damage, ferroptosis, cell cycle progression and apoptosis as well as migration, proliferation, and epithelial-mesenchymal transition.
Author: | Jörg Fahrer, Simon Wittmann, Ann-Cathrin Wolf, Tina Kostka |
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URN: | urn:nbn:de:hbz:386-kluedo-77131 |
ISSN: | 2076-3921 |
Parent Title (English): | Antioxidants |
Publisher: | MDPI |
Document Type: | Article |
Language of publication: | English |
Date of Publication (online): | 2023/11/10 |
Year of first Publication: | 2023 |
Publishing Institution: | Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau |
Date of the Publication (Server): | 2024/02/28 |
Tag: | colorectal carcinogenesis; heme oxygenase-1; reactive oxygen species |
Volume: | 12 |
Issue: | 11 |
Article Number: | 1989 |
Page Number: | 32 |
Source: | https://doi.org/10.3390/antiox12111989 |
Faculties / Organisational entities: | Kaiserslautern - Fachbereich Chemie |
DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 540 Chemie |
Collections: | Open-Access-Publikationsfonds |
Licence (German): | Zweitveröffentlichung |