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- A multiscale modeling approach to glioma invasion with therapy (2015)
- We consider the multiscale model for glioma growth introduced in a previous work and extend it to account for therapy effects. Thereby, three treatment strategies involving surgical resection, radio-, and chemotherapy are compared for their efficiency. The chemotherapy relies on inhibiting the binding of cell surface receptors to the surrounding tissue, which impairs both migration and proliferation.

- A stochastic model featuring acid induced gaps during tumor progression. (2015)
- In this paper we propose a phenomenological model for the formation of an interstitial gap between the tumor and the stroma. The gap is mainly filled with acid produced by the progressing edge of the tumor front. Our setting extends existing models for acid-induced tumor invasion models to incorporate several features of local invasion like formation of gaps, spikes, buds, islands, and cavities. These behaviors are obtained mainly due to the random dynamics at the intracellular level, the go-or-grow-or-recede dynamics on the population scale, together with the nonlinear coupling between the microscopic (intracellular) and macroscopic (population) levels. The wellposedness of the model is proved using the semigroup technique and 1D and 2D numerical simulations are performed to illustrate model predictions and draw conclusions based on the observed behavior.

- A nonlocal sample dependence SDE-PDE system modeling proton dynamics in a tumor (2015)
- A nonlocal stochastic model for intra- and extracellular proton dynamics in a tumor is proposed. The intracellular dynamics is governed by an SDE coupled to a reaction-diffusion equation for the extracellular proton concentration on the macroscale. In a more general context the existence and uniqueness of solutions for local and nonlocal SDE-PDE systems are established allowing, in particular, to analyze the proton dynamics model both, in its local version and the case with nonlocal path dependence. Numerical simulations are performed to illustrate the behavior of solutions, providing some insights into the effects of randomness on tumor acidity.

- On the History of Differential-Algebraic Equations (2015)
- To write about the history of a subject is a challenge that grows with the number of pages as the original goal of completeness is turning more and more into an impossibility. With this in mind, the present article takes a very narrow approach and uses personal side trips and memories on conferences, workshops, and summer schools as the stage for some of the most important protagonists and their contributions to the field of Differential-Algebraic Equations (DAEs).

- Competitive Algorithms for Multistage Online Scheduling (2015)
- We study an online flow shop scheduling problem where each job consists of several tasks that have to be completed in t different stages and the goal is to maximize the total weight of accepted jobs. The set of tasks of a job contains one task for each stage and each stage has a dedicated set of identical parallel machines corresponding to it that can only process tasks of this stage. In order to gain the weight (profit) associated with a job j, each of its tasks has to be executed between a task-specific release date and deadline subject to the constraint that all tasks of job j from stages 1, …, i-1 have to be completed before the task of the ith stage can be started. In the online version, jobs arrive over time and all information about the tasks of a job becomes available at the release date of its first task. This model can be used to describe production processes in supply chains when customer orders arrive online. We show that even the basic version of the offline problem with a single machine in each stage, unit weights, unit processing times, and fixed execution times for all tasks (i.e., deadline minus release date equals processing time) is APX-hard. Moreover, we show that the approximation ratio of any polynomial-time approximation algorithm for this basic version of the problem must depend on the number t of stages. For the online version of the basic problem, we provide a (2t-1)-competitive deterministic online algorithm and a matching lower bound. Moreover, we provide several (sometimes tight) upper and lower bounds on the competitive ratio of online algorithms for several generalizations of the basic problem involving different weights, arbitrary release dates and deadlines, different processing times of tasks, and several identical machines per stage.

- A new solution approach for solving the 2-facility location problem in the plane with block norms (2015)
- Motivated by the time-dependent location problem over T time-periods introduced in Maier and Hamacher (2015) we consider the special case of two time-steps, which was shown to be equivalent to the static 2-facility location problem in the plane. Geometric optimality conditions are stated for the median objective. When using block norms, these conditions are used to derive a polygon grid inducing a subdivision of the plane based on normal cones, yielding a new approach to solve the 2-facility location problem in polynomial time. Combinatorial algorithms for the 2-facility location problem based on geometric properties are deduced and their complexities are analyzed. These methods differ from others as they are completely working on geometric objects to derive the optimal solution set.

- Discrete Parallel Machine Makespan ScheLoc Problem (2015)
- Scheduling-Location (ScheLoc) Problems integrate the separate fields of scheduling and location problems. In ScheLoc Problems the objective is to find locations for the machines and a schedule for each machine subject to some production and location constraints such that some scheduling object- ive is minimized. In this paper we consider the Discrete Parallel Machine Makespan (DPMM) ScheLoc Problem where the set of possible machine loc- ations is discrete and a set of n jobs has to be taken to the machines and processed such that the makespan is minimized. Since the separate location and scheduling problem are both NP-hard, so is the corresponding ScheLoc Problem. Therefore, we propose an integer programming formulation and different versions of clustering heuristics, where jobs are split into clusters and each cluster is assigned to one of the possible machine locations. Since the IP formulation can only be solved for small scale instances we propose several lower bounds to measure the quality of the clustering heuristics. Ex- tensive computational tests show the efficiency of the heuristics.

- Robust Flows with Losses and Improvability in Evacuation Planning (2014)
- We consider a network flow problem, where the outgoing flow is reduced by a certain percentage in each node. Given a maximum amount of flow that can leave the source node, the aim is to find a solution that maximizes the amount of flow which arrives at the sink. Starting from this basic model, we include two new, additional aspects: On the one hand, we are able to reduce the loss at some of the nodes; on the other hand, the exact loss values are not known, but may come from a discrete uncertainty set of exponential size. Applications for problems of this type can be found in evacuation planning, where one would like to improve the safety of nodes such that the number of evacuees reaching safety is maximized. We formulate the resulting robust flow problem with losses and improvability as a mixed-integer program for finitely many scenarios, and present an iterative scenario-generation procedure that avoids the inclusion of all scenarios from the beginning. In a computational study using both randomly generated instance and realistic data based on the city of Nice, France, we compare our solution algorithms.

- A Bicriteria Approach to Robust Optimization (2014)
- The classic approach in robust optimization is to optimize the solution with respect to the worst case scenario. This pessimistic approach yields solutions that perform best if the worst scenario happens, but also usually perform bad on average. A solution that optimizes the average performance on the other hand lacks in worst-case performance guarantee. In practice it is important to find a good compromise between these two solutions. We propose to deal with this problem by considering it from a bicriteria perspective. The Pareto curve of the bicriteria problem visualizes exactly how costly it is to ensure robustness and helps to choose the solution with the best balance between expected and guaranteed performance. Building upon a theoretical observation on the structure of Pareto solutions for problems with polyhedral feasible sets, we present a column generation approach that requires no direct solution of the computationally expensive worst-case problem. In computational experiments we demonstrate the effectivity of both the proposed algorithm, and the bicriteria perspective in general.

- Hierarchical Edge Colorings and Rehabilitation Therapy Planning in Germany (2014)
- In this paper we give an overview on the system of rehabilitation clinics in Germany in general and the literature on patient scheduling applied to rehabilitation facilities in particular. We apply a class-teacher model developed to this environment and then generalize it to meet some of the specific constraints of inpatient rehabilitation clinics. To this end we introduce a restricted edge coloring on undirected bipartite graphs which is called group-wise balanced. The problem considered is called patient-therapist-timetable problem with group-wise balanced constraints (PTTPgb). In order to specify weekly schedules further such that they produce a reasonable allocation to morning/afternoon (second level decision) and to the single periods (third level decision) we introduce (hierarchical PTTPgb). For the corresponding model, the hierarchical edge coloring problem, we present some first feasibility results.