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- On The Recoverable Robust Traveling Salesman Problem (2014)
- We consider an uncertain traveling salesman problem, where distances between nodes are not known exactly, but may stem from an uncertainty set of possible scenarios. This uncertainty set is given as intervals with an additional bound on the number of distances that may deviate from their expected, nominal value. A recoverable robust model is proposed, that allows a tour to change a bounded number of edges once a scenario becomes known. As the model contains an exponential number of constraints and variables, an iterative algorithm is proposed, in which tours and scenarios are computed alternately. While this approach is able to find a provably optimal solution to the robust model, it also needs to solve increasingly complex subproblems. Therefore, we also consider heuristic solution procedures based on local search moves using a heuristic estimate of the actual objective function. In computational experiments, these approaches are compared. Finally, an alternative recovery model is discussed, where a second-stage recovery tour is not required to visit all nodes of the graph. We show that the previously NP-hard evaluation of a fixed solution now becomes solvable in polynomial time.

- Optimization Models to Enhance Resilience in Evacuation Planning (2014)
- We argue that the concepts of resilience in engineering science and robustness in mathematical optimization are strongly related. Using evacuation planning as an example application, we demonstrate optimization techniques to improve solution resilience. These include a direct modelling of the uncertainty for stochastic or robust optimization, as well as taking multiple objective functions into account.

- Effective equations for anisotropic glioma spread with proliferation: a multiscale approach (2014)
- Glioma is a common type of primary brain tumor, with a strongly invasive potential, often exhibiting nonuniform, highly irregular growth. This makes it difficult to assess the degree of extent of the tumor, hence bringing about a supplementary challenge for the treatment. It is therefore necessary to understand the migratory behavior of glioma in greater detail. In this paper we propose a multiscale model for glioma growth and migration. Our model couples the microscale dynamics (reduced to the binding of surface receptors to the surrounding tissue) with a kinetic transport equation for the cell density on the mesoscopic level of individual cells. On the latter scale we also include the proliferation of tumor cells via effects of interaction with the tissue. An adequate parabolic scaling yields a convection-diffusion-reaction equation, for which the coefficients can be explicitly determined from the information about the tissue obtained by diffusion tensor imaging. Numerical simulations relying on DTI measurements confirm the biological findings that glioma spreads along white matter tracts.

- Numerical schemes for networks of hyperbolic conservation laws (2014)
- In this paper we propose a procedure to extend classical numerical schemes for hyperbolic conservation laws to networks of hyperbolic conservation laws. At the junctions of the network we solve the given coupling conditions and minimize the contributions of the outgoing numerical waves. This flexible procedure allows us to also use central schemes at the junctions. Several numerical examples are considered to investigate the performance of this new approach compared to the common Godunov solver and exact solutions.

- A multiscale model for acid-mediated tumor invasion: therapy approaches (2014)
- Starting from the two-scale model for pH-taxis of cancer cells introduced in [1], we consider here an extension accounting for tumor heterogeneity w.r.t. treatment sensitivity and a treatment approach including chemo- and radiotherapy. The effect of peritumoral region alkalinization on such therapeutic combination is investigated with the aid of numerical simulations.

- First Order Algorithms in Variational Image Processing (2014)
- Variational methods in imaging are nowadays developing towards a quite universal and exible tool, allowing for highly successful approaches on tasks like denoising, deblurring, inpainting, segmentation, super-resolution, disparity, and optical flow estimation. The overall structure of such approaches is of the form D(Ku) + alpha R(u) to min_u ; where the functional D is a data fidelity term also depending on some input data f and measuring the deviation of Ku from such and R is a regularization functional. Moreover K is a (often linear) forward operator modeling the dependence of data on an underlying image, and alpha is a positive regularization parameter. While D is often smooth and (strictly) convex, the current practice almost exclusively uses nonsmooth regularization functionals. The majority of successful techniques is using nonsmooth and convex functionals like the total variation and generalizations thereof, cf. [28, 31, 40], or l_1-norms of coeefficients arising from scalar products with some frame system, cf. [73] and references therein. The efficient solution of such variational problems in imaging demands for appropriate algorithms. Taking into account the specific structure as a sum of two very different terms to be minimized, splitting algorithms are a quite canonical choice. Consequently this field has revived the interest in techniques like operator splittings or augmented Lagrangians. In this chapter we shall provide an overview of methods currently developed and recent results as well as some computational studies providing a comparison of different methods and also illustrating their success in applications. We start with a very general viewpoint in the first sections, discussing basic notations, properties of proximal maps, firmly non-expansive and averaging operators, which form the basis of further convergence arguments. Then we proceed to a discussion of several state-of-the art algorithms and their (theoretical) convergence properties. After a section discussing issues related to the use of analogous iterative schemes for ill-posed problems, we present some practical convergence studies in numerical examples related to PET and spectral CT reconstruction.

- A Framework for Shape Optimization in the Context of Isogeometric Analysis (2014)
- We develop a framework for shape optimization problems under state equation con- straints where both state and control are discretized by B-splines or NURBS. In other words, we use isogeometric analysis (IGA) for solving the partial differential equation and a nodal approach to change domains where control points take the place of nodes and where thus a quite general class of functions for representing optimal shapes and their boundaries becomes available. The minimization problem is solved by a gradient descent method where the shape gradient will be defined in isogeometric terms. This gradient is obtained following two schemes, optimize first–discretize then and, reversely, discretize first–optimize then. We show that for isogeometric analysis, the two schemes yield the same discrete system. Moreover, we also formulate shape optimization with respect to NURBS in the optimize first ansatz which amounts to finding optimal control points and weights simultaneously. Numerical tests illustrate the theory.

- Hierarchical Edge Colorings and Rehabilitation Therapy Planning in Germany (2014)
- In this paper we give an overview on the system of rehabilitation clinics in Germany in general and the literature on patient scheduling applied to rehabilitation facilities in particular. We apply a class-teacher model developed to this environment and then generalize it to meet some of the specific constraints of inpatient rehabilitation clinics. To this end we introduce a restricted edge coloring on undirected bipartite graphs which is called group-wise balanced. The problem considered is called patient-therapist-timetable problem with group-wise balanced constraints (PTTPgb). In order to specify weekly schedules further such that they produce a reasonable allocation to morning/afternoon (second level decision) and to the single periods (third level decision) we introduce (hierarchical PTTPgb). For the corresponding model, the hierarchical edge coloring problem, we present some first feasibility results.

- A stochastic multiscale model for acid mediated cancer invasion (2014)
- Cancer research is not only a fast growing field involving many branches of science, but also an intricate and diversified field rife with anomalies. One such anomaly is the consistent reliance of cancer cells on glucose metabolism for energy production even in a normoxic environment. Glycolysis is an inefficient pathway for energy production and normally is used during hypoxic conditions. Since cancer cells have a high demand for energy (e.g. for proliferation) it is somehow paradoxical for them to rely on such a mechanism. An emerging conjecture aiming to explain this behavior is that cancer cells preserve this aerobic glycolytic phenotype for its use in invasion and metastasis. We follow this hypothesis and propose a new model for cancer invasion, depending on the dynamics of extra- and intracellular protons, by building upon the existing ones. We incorporate random perturbations in the intracellular proton dynamics to account for uncertainties affecting the cellular machinery. Finally, we address the well-posedness of our setting and use numerical simulations to illustrate the model predictions.

- A Comprehensive Evacuation Planning Model and Genetic Solution Algorithm (2014)
- We consider the problem of evacuating an urban area caused by a natural or man-made disaster. There are several planning aspects that need to be considered in such a scenario, which are usually considered separately, due to their computational complexity. These aspects include: Which shelters are used to accommodate evacuees? How to schedule public transport for transit-dependent evacuees? And how do public and individual traffic interact? Furthermore, besides evacuation time, also the risk of the evacuation needs to be considered. We propose a macroscopic multi-criteria optimization model that includes all of these questions simultaneously. As a mixed-integer programming formulation cannot handle instances of real-world size, we develop a genetic algorithm of NSGA-II type that is able to generate feasible solutions of good quality in reasonable computation times. We extend the applicability of these methods by also considering how to aggregate instance data, and how to generate solutions for the original instance starting from a reduced solution. In computational experiments using real-world data modelling the cities of Nice in France and Kaiserslautern in Germany, we demonstrate the effectiveness of our approach and compare the trade-off between different levels of data aggregation.