## Fachbereich Mathematik

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- A new sequential extraction heuristic for optimising the delivery of cancer radiation treatment using multileaf collimators (2008)
- Finding a delivery plan for cancer radiation treatment using multileaf collimators operating in ''step-and-shoot mode'' can be formulated mathematically as a problem of decomposing an integer matrix into a weighted sum of binary matrices having the consecutive-ones property - and sometimes other properties related to the collimator technology. The efficiency of the delivery plan is measured by both the sum of weights in the decomposition, known as the total beam-on time, and the number of different binary matrices appearing in it, referred to as the cardinality, the latter being closely related to the set-up time of the treatment. In practice, the total beam-on time is usually restricted to its minimum possible value, (which is easy to find), and a decomposition that minimises cardinality (subject to this restriction) is sought.

- Minimum Cut Bases in Undirected Networks (2007)
- Given an undirected, connected network G = (V,E) with weights on the edges, the cut basis problem is asking for a maximal number of linear independent cuts such that the sum of the cut weights is minimized. Surprisingly, this problem has not attained as much attention as its graph theoretic counterpart, the cycle basis problem. We consider two versions of the problem, the unconstrained and the fundamental cut basis problem. For the unconstrained case, where the cuts in the basis can be of an arbitrary kind, the problem can be written as a multiterminal network flow problem and is thus solvable in strongly polynomial time. The complexity of this algorithm improves the complexity of the best algorithms for the cycle basis problem, such that it is preferable for cycle basis problems in planar graphs. In contrast, the fundamental cut basis problem, where all cuts in the basis are obtained by deleting an edge, each, from a spanning tree T is shown to be NP-hard. We present heuristics, integer programming formulations and summarize first experiences with numerical tests.

- Scheduling and Location (ScheLoc): Makespan Problem with Variable Release Dates (2007)
- While in classical scheduling theory the locations of machines are assumed to be fixed we will show how to tackle location and scheduling problems simultaneously. Obviously, this integrated approach enhances the modeling power of scheduling for various real-life problems. In this paper, we present in an exemplary way theory and a solution algorithm for a specific type of a scheduling and a rather general, planar location problem, respectively. More general results and a report on numerical tests will be presented in a subsequent paper.

- Decomposition of Matrices and Static Multileaf Collimators: A Survey (2006)
- Multileaf Collimators (MLC) consist of (currently 20-100) pairs of movable metal leaves which are used to block radiation in Intensity Modulated Radiation Therapy (IMRT). The leaves modulate a uniform source of radiation to achieve given intensity profiles. The modulation process is modeled by the decomposition of a given non-negative integer matrix into a non-negative linear combination of matrices with the (strict) consecutive ones property.

- Acquisition Prioritization: A Multicriteria Approach Based on a Case Study (2006)
- Selection of new projects is one of the major decision making activities in any company. Given a set of potential projects to invest, a subset which matches the company's strategy and internal resources best has to be selected. In this paper, we propose a multicriteria model for portfolio selection of projects, where we take into consideration that each of the potential projects has several - usually conflicting - values.

- Semi-Simultaneous Flows and Binary Constrained (Integer) Linear Programs (2006)
- Linear and integer programs are considered whose coefficient matrices can be partitioned into K consecutive ones matrices. Mimicking the special case of K=1 which is well-known to be equivalent to a network flow problem we show that these programs can be transformed to a generalized network flow problem which we call semi-simultaneous (se-sim) network flow problem. Feasibility conditions for se-sim flows are established and methods for finding initial feasible se-sim flows are derived. Optimal se-sim flows are characterized by a generalization of the negative cycle theorem for the minimum cost flow problem. The issue of improving a given flow is addressed both from a theoretical and practical point of view. The paper concludes with a summary and some suggestions for possible future work in this area.

- Hub Cover and Hub Center Problems (2006)
- Using covering problems (CoP) combined with binary search is a well-known and successful solution approach for solving continuous center problems. In this paper, we show that this is also true for center hub location problems in networks. We introduce and compare various formulations for hub covering problems (HCoP) and analyse the feasibility polyhedron of the most promising one. Computational results using benchmark instances are presented. These results show that the new solution approach performs better in most examples.

- Multiple Objective Minimum Cost Flow Problems: A Review (2005)
- In this paper, theory and algorithms for solving the multiple objective minimum cost flow problem are reviewed. For both the continuous and integer case exact and approximation algorithms are presented. In addition, a section on compromise solutions summarizes corresponding results. The reference list consists of all papers known to the autheors which deal with the multiple objective minimum cost flow problem.

- Finding Representative Systems for Discrete Bicriteria Optimization Problems by Box Algorithms (2005)
- Given a discrete bicriteria optimization problem (DBOP), we propose two versions of an approximation procedure, the box algorithm, which results in a representation of the complete set of nondominated solutions by a finite representative system Rep satisfying the following quality features.

- Decomposition of Integer Matrices and Multileaf Collimator Sequencing (2004)
- In this paper we consider the problem of decomposing an integer matrix into a weighted sum of binary matrices that have to strict consecutive ones property.