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We consider storage loading problems where items with uncertain weights have
to be loaded into a storage area, taking into account stacking and
payload constraints. Following the robust optimization paradigm, we propose
strict and adjustable optimization models for finite and interval-based
uncertainties. To solve these problems, exact decomposition and heuristic
solution algorithms are developed.
For strict robustness, we also present a compact formulation based
on a characterization of worst-case scenarios.
Computational results show that computation times and algorithm
gaps are reasonable for practical applications.
Furthermore, we find that the robustness concepts show different
potential depending on the type of data being used.

Scheduling-Location (ScheLoc) Problems integrate the separate fields of
scheduling and location problems. In ScheLoc Problems the objective is to
find locations for the machines and a schedule for each machine subject to
some production and location constraints such that some scheduling object-
ive is minimized. In this paper we consider the Discrete Parallel Machine
Makespan (DPMM) ScheLoc Problem where the set of possible machine loc-
ations is discrete and a set of n jobs has to be taken to the machines and
processed such that the makespan is minimized. Since the separate location
and scheduling problem are both NP-hard, so is the corresponding ScheLoc
Problem. Therefore, we propose an integer programming formulation and
different versions of clustering heuristics, where jobs are split into clusters
and each cluster is assigned to one of the possible machine locations. Since
the IP formulation can only be solved for small scale instances we propose
several lower bounds to measure the quality of the clustering heuristics. Ex-
tensive computational tests show the efficiency of the heuristics.

A new solution approach for solving the 2-facility location problem in the plane with block norms
(2015)

Motivated by the time-dependent location problem over T time-periods introduced in
Maier and Hamacher (2015) we consider the special case of two time-steps, which was shown
to be equivalent to the static 2-facility location problem in the plane. Geometric optimality
conditions are stated for the median objective. When using block norms, these conditions
are used to derive a polygon grid inducing a subdivision of the plane based on normal cones,
yielding a new approach to solve the 2-facility location problem in polynomial time. Combinatorial algorithms for the 2-facility location problem based on geometric properties are
deduced and their complexities are analyzed. These methods differ from others as they are
completely working on geometric objects to derive the optimal solution set.

We study an online flow shop scheduling problem where each job consists of several tasks that have to be completed in t different stages and the goal is to maximize the total weight of accepted jobs.
The set of tasks of a job contains one task for each stage and each stage has a dedicated set of identical parallel machines corresponding to it that can only process tasks of this stage. In order to gain the weight (profit) associated with a job j, each of its tasks has to be executed between a task-specific release date and deadline subject to the constraint that all tasks of job j from stages 1, …, i-1 have to be completed before the task of the ith stage can be started. In the online version, jobs arrive over time and all information about the tasks of a job becomes available at the release date of its first task. This model can be used to describe production processes in supply chains when customer orders arrive online.
We show that even the basic version of the offline problem with a single machine in each stage, unit weights, unit processing times, and fixed execution times for all tasks (i.e., deadline minus release date equals processing time) is APX-hard. Moreover, we show that the approximation ratio of any polynomial-time approximation algorithm for this basic version of the problem must depend on the number t of stages.
For the online version of the basic problem, we provide a (2t-1)-competitive deterministic online algorithm and a matching lower bound. Moreover, we provide several (sometimes tight) upper and lower bounds on the competitive ratio of online algorithms for several generalizations of the basic problem involving different weights, arbitrary release dates and deadlines, different processing times of tasks, and several identical machines per stage.

To write about the history of a subject is a challenge that grows with the number of pages as the original goal of completeness is turning more and more into an impossibility. With this in mind, the present article takes a very narrow approach and uses personal side trips and memories on conferences,
workshops, and summer schools as the stage for some of the most important protagonists and their contributions to the field of Differential-Algebraic Equations (DAEs).

A nonlocal stochastic model for intra- and extracellular proton dynamics in a tumor is proposed.
The intracellular dynamics is governed by an SDE coupled to a reaction-diffusion
equation for the extracellular proton concentration on the macroscale. In a more general context
the existence and uniqueness of solutions for local and nonlocal
SDE-PDE systems are established allowing, in particular, to analyze the proton dynamics model both,
in its local version and the case with nonlocal path dependence.
Numerical simulations are performed
to illustrate the behavior of solutions, providing some insights into the effects of randomness on tumor acidity.

In this paper we propose a phenomenological model for the formation of an interstitial gap between the tumor and the stroma. The gap
is mainly filled with acid produced by the progressing edge of the tumor front. Our setting extends existing models for acid-induced tumor invasion models to incorporate
several features of local invasion like formation of gaps, spikes, buds, islands, and cavities. These behaviors are obtained mainly due to the random dynamics at the intracellular
level, the go-or-grow-or-recede dynamics on the population scale, together with the nonlinear coupling between the microscopic (intracellular) and macroscopic (population)
levels. The wellposedness of the model is proved using the semigroup technique and 1D and 2D numerical simulations are performed to illustrate model predictions and draw
conclusions based on the observed behavior.

We consider the multiscale model for glioma growth introduced in a previous work and extend it to account
for therapy effects. Thereby, three treatment strategies involving surgical resection, radio-, and
chemotherapy are compared for their efficiency. The chemotherapy relies on inhibiting the binding
of cell surface receptors to the surrounding tissue, which impairs both migration and proliferation.

A single facility problem in the plane is considered, where an optimal location has to be
identified for each of finitely many time-steps with respect to time-dependent weights and
demand points. It is shown that the median objective can be reduced to a special case of the
static multifacility median problem such that results from the latter can be used to tackle the
dynamic location problem. When using block norms as distance measure between facilities,
a Finite Dominating Set (FDS) is derived. For the special case with only two time-steps, the
resulting algorithm is analyzed with respect to its worst-case complexity. Due to the relation
between dynamic location problems for T time periods and T-facility problems, this algorithm
can also be applied to the static 2-facility location problem.

We consider the problem of finding efficient locations of surveillance cameras, where we distinguish
between two different problems. In the first, the whole area must be monitored and the number of cameras
should be as small as possible. In the second, the goal is to maximize the monitored area for a fixed number of
cameras. In both of these problems, restrictions on the ability of the cameras, like limited depth of view or range
of vision are taken into account. We present solution approaches for these problems and report on results of
their implementations applied to an authentic problem. We also consider a bicriteria problem with two objectives:
maximizing the monitored area and minimizing the number of cameras, and solve it for our study case.

We consider a network flow problem, where the outgoing flow is reduced by a certain percentage in each node. Given a maximum amount of flow that can leave the source node, the aim is to find a solution that maximizes the amount of flow which arrives at the sink.
Starting from this basic model, we include two new, additional aspects: On the one hand, we are able to reduce the loss at some of the nodes; on the other hand, the exact loss values are not known, but may come from a discrete uncertainty set of exponential size.
Applications for problems of this type can be found in evacuation planning, where one would like to improve the safety of nodes such that the number of evacuees reaching safety is maximized.
We formulate the resulting robust flow problem with losses and improvability as a mixed-integer program for finitely many scenarios, and present an iterative scenario-generation procedure that avoids the inclusion of all scenarios from the beginning. In a computational study using both randomly generated instance and realistic data based on the city of Nice, France, we compare our solution algorithms.

The classic approach in robust optimization is to optimize the solution with respect to the worst case scenario. This pessimistic approach yields solutions that perform best if the worst scenario happens, but also usually perform bad on average. A solution that optimizes the average performance on the other hand lacks in worst-case performance guarantee.
In practice it is important to find a good compromise between these two solutions. We propose to deal with this problem by considering it from a bicriteria perspective. The Pareto curve of the bicriteria problem visualizes exactly how costly it is to ensure robustness and helps to choose the solution with the best balance between expected and guaranteed performance.
Building upon a theoretical observation on the structure of Pareto solutions for problems with polyhedral feasible sets, we present a column generation approach that requires no direct solution of the computationally expensive worst-case problem. In computational experiments we demonstrate the effectivity of both the proposed algorithm, and the bicriteria perspective in general.

Geometric Programming is a useful tool with a wide range of applications in engineering. As in real-world problems input data is likely to be affected by uncertainty, Hsiung, Kim, and Boyd introduced robust geometric programming to include the uncertainty in the optimization process. They also developed a tractable approximation method to tackle this problem. Further, they pose the question whether there exists a tractable reformulation of their robust geometric programming model instead of only an approximation method. We give a negative answer to this question by showing that robust geometric programming is co-NP hard in its natural posynomial form.

The sink location problem is a combination of network flow and location problems: From a given set of nodes in a flow network a minimum cost subset \(W\) has to be selected such that given supplies can be transported to the nodes in \(W\). In contrast to its counterpart, the source location problem which has already been studied in the literature, sinks have, in general, a limited capacity. Sink location has a decisive application in evacuation planning, where the supplies correspond to the number of evacuees and the sinks to emergency shelters.
We classify sink location problems according to capacities on shelter nodes, simultaneous or non-simultaneous flows, and single or multiple assignments of evacuee groups to shelters. Resulting combinations are interpreted in the evacuation context and analyzed with respect to their worst-case complexity status.
There are several approaches to tackle these problems: Generic solution methods for uncapacitated problems are based on source location and modifications of the network. In the capacitated case, for which source location cannot be applied, we suggest alternative approaches which work in the original network. It turns out that latter class algorithms are superior to the former ones. This is established in numerical tests including random data as well as real world data from the city of Kaiserslautern, Germany.

Building interoperation among separately developed software units requires checking their conceptual assumptions and constraints. However, eliciting such assumptions and constraints is time consuming and is a challenging task as it requires analyzing each of the interoperating software units. To address this issue we proposed a new conceptual interoperability analysis approach which aims at decreasing the analysis cost and the conceptual mismatches between the interoperating software units. In this report we present the design of a planned controlled experiment for evaluating the effectiveness, efficiency, and acceptance of our proposed conceptual interoperability analysis approach. The design includes the study objectives, research questions, statistical hypotheses, and experimental design. It also provides the materials that will be used in the execution phase of the planned experiment.

A new algorithm for optimization problems with three objective functions is presented which computes a representation for the set of nondominated points. This representation is guaranteed to have a desired coverage error and a bound on the number of iterations needed by the algorithm to meet this coverage error is derived. Since the representation does not necessarily contain nondominated points only, ideas to calculate bounds for the representation error are given. Moreover, the incorporation of domination during the algorithm and other quality measures are discussed.

The ordered weighted averaging objective (OWA) is an aggregate function over multiple optimization criteria which received increasing attention by the research community over the last decade. Different to the ordered weighted sum, weights are attached to ordered objective functions (i.e., a weight for the largest value, a weight for the second-largest value and so on). As this contains max-min or worst-case optimization as a special case, OWA can also be considered as an alternative approach to robust optimization.
For linear programs with OWA objective, compact reformulations exist, which result in extended linear programs. We present new such reformulation models with reduced size. A computational comparison indicates that these formulations improve solution times.

We consider an uncertain traveling salesman problem, where distances between nodes are not known exactly, but may stem from an uncertainty set of possible scenarios. This uncertainty set is given as intervals with an additional bound on the number of distances that may deviate from their expected, nominal value.
A recoverable robust model is proposed, that allows a tour to change a bounded number of edges once a scenario becomes known. As the model contains an exponential number of constraints and variables, an iterative algorithm is proposed, in which tours and scenarios are computed alternately.
While this approach is able to find a provably optimal solution to the robust model, it also needs to solve increasingly complex subproblems. Therefore, we also consider heuristic solution procedures based on local search moves using a heuristic estimate of the actual objective function. In computational experiments, these approaches are compared.
Finally, an alternative recovery model is discussed, where a second-stage recovery tour is not required to visit all nodes of the graph. We show that the previously NP-hard evaluation of a fixed solution now becomes solvable in polynomial time.

We argue that the concepts of resilience in engineering science and robustness in mathematical optimization are strongly related. Using evacuation planning as an example application, we demonstrate optimization techniques to improve solution resilience. These include a direct modelling of the uncertainty for stochastic or robust optimization, as well as taking multiple objective functions into account.

Glioma is a common type of primary brain tumor, with a strongly invasive potential, often exhibiting nonuniform, highly irregular growth. This makes it difficult to assess
the degree of extent of the tumor, hence bringing about a supplementary challenge for the treatment. It is therefore necessary to understand the
migratory behavior of glioma in greater detail.
In this paper we propose a multiscale model for glioma growth and migration. Our model couples the microscale dynamics (reduced to the binding of surface receptors to the
surrounding tissue) with a kinetic transport equation for the cell density on the mesoscopic level of individual cells. On the latter scale we also include the
proliferation of tumor cells via effects of interaction with the tissue. An adequate parabolic scaling yields a convection-diffusion-reaction equation, for which the coefficients
can be explicitly determined from the information about the tissue obtained by diffusion tensor imaging. Numerical simulations relying on DTI measurements confirm the biological
findings that glioma spreads
along white matter tracts.