Cancer cell migration is an essential feature in the process of tumor spread and establishing of metastasis. It characterizes the invasion observed on the level of the cell population, but it is also tightly connected to the events taking place on the subcellular level. These are conditioning the motile and proliferative behavior of the cells, but are also influenced by it. In this work we propose a multiscale model linking these two levels and aiming to assess their interdependence. On the subcellular, microscopic scale it accounts for integrin binding to soluble and insoluble components present in the peritumoral environment, which is seen as the onset of biochemical events leading to changes in the cell's ability to contract and modify its shape. On the macroscale of the cell population this leads to modifications in the diffusion and haptotaxis performed by the tumor cells and implicitly to changes in the tumor environment. We prove the (local) well posedness of our model and perform numerical simulations in order to illustrate the model predictions.
Most of the evolution in ambient assisted living is due to embedded
systems that dynamically adapt themself to react to environmental
changes or component/subsystem failures to maintain a certain level of
safety. Following this evolution fault tree analysis techniques have been
extended with concept for dynamic adaptation but resulting techniques
such as dynamic fault trees or state event fault trees analysis are not
widely used as expected.
In this report we describe a controlled experiment to analyze these two
techniques with regard to their applicability and efficiency in modeling
dynamic behavior of ambient assisted living systems.
Results of the experiment show that Dynamic Fault Trees are easier and more effective
to use, although they produce better results (models) with State Events Fault Trees.
Most innovation in the automotive industry is driven by embedded systems. They make usage of dynamic adaption to environmental changes or component/subsystem failures for remaining safe. Following this evolution, fault tree analysis techniques have been extended with concept for dynamic adaptation but resulting techniques like state event fault tree analysis, are not widely used in practice.
In this report we present the results of a controlled experiment that analyze these two techniques (State Events Fault Trees and Faul trees combined with markov chains) with regard to their applicability and efficiency in modeling dynamic behavior of dynamic embedded systems.
The experiment was conducted with students of the TU Kaiserslautern to modeli different safety aspects of an ambient assisted living system.
The main results of the experiment show that SEFTs where more easy and effective to use.
It is well known that the greedy algorithm solves matroid base problems for all linear cost functions and is, in fact, correct if and only if the underlying combinatorial structure of the problem is a matroid. Moreover, the algorithm can be applied to problems with sum, bottleneck, algebraic sum or \(k\)-sum objective functions.
Conditional Compilation (CC) is frequently used as a variation mechanism in software product lines (SPLs). However, as a SPL evolves the variable code realized by CC erodes in the sense that it becomes overly complex and difficult to understand and maintain. As a result, the SPL productivity goes down and puts expected advantages more and more at risk. To investigate the variability erosion and keep the productivity above a sufficiently good level, in this paper we 1) investigate several erosion symptoms in an industrial SPL; 2) present a variability improvement process that includes two major improvement strategies. While one strategy is to optimize variable code within the scope of CC, the other strategy is to transition CC to a new variation mechanism called Parameterized Inclusion. Both of these two improvement strategies can be conducted automatically, and the result of CC optimization is provided. Related issues such as applicability and cost of the improvement are also discussed.
We consider the problem of evacuating a region with the help of buses. For a given set of possible collection points where evacuees gather, and possible shelter locations where evacuees are brought to, we need to determine both collection points and shelters we would like to use, and bus routes that evacuate the region in minimum time.
We model this integrated problem using an integer linear program, and present a branch-cut-and-price algorithm that generates bus tours in its pricing step. In computational experiments we show that our approach is able to solve instances of realistic size in sufficient time for practical application, and considerably outperforms the usage of a generic ILP solver.
In the present paper scalar macroscopic models for traffic and pedestrian flows are coupled and the resulting system is investigated numerically. For the traffic flow the classical
Lighthill-Whitham model on a network of roads and for the pedestrian flow the Hughes
model are used. These models are coupled via terms in the fundamental diagrams mod-
eling an influence of the traffic and pedestrian flow on the maximal velocities of the
corresponding models. Several physical situations, where pedestrians and cars interact,
As a Software Product Line (SPL) evolves with increasing number of features and feature values, the feature correlations become extremely intricate, and the specifications of these correlations tend to be either incomplete or inconsistent with their realizations, causing misconfigurations in practice. In order to guide product configuration processes, we present a solution framework to recover complex feature correlations from existing product configurations. These correlations are further pruned automatically and validated by domain experts. During implementation, we use association mining techniques to automatically extract strong association rules as potential feature correlations. This approach is evaluated using a large-scale industrial SPL in the embedded system domain, and finally we identify a large number of complex feature correlations.
In this paper we consider a multivariate switching model, with constant states means
and covariances. In this model, the switching mechanism between the basic states of
the observed time series is controlled by a hidden Markov chain. As illustration, under
Gaussian assumption on the innovations and some rather simple conditions, we prove
the consistency and asymptotic normality of the maximum likelihood estimates of the model parameters.
An extension of the finite element method–flux corrected transport stabilization (FEM-FCT) for hyperbolic problems in the context of partial differential-
algebraic equations (PDAEs) is proposed. Given a local extremum diminishing
property of the spatial discretization, the positivity preservation of the one-step
θ−scheme when applied to the time integration of the resulting differential-
algebraic equation (DAE) is shown, under a mild restriction on the time step-
size. As crucial tool in the analysis, the Drazin inverse and the corresponding
Drazin ODE are explicitly derived. Numerical results are presented for non-
constant and time-dependent boundary conditions in one space dimension and
for a two-dimensional advection problem where the advection proceeds skew to