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We investigate in how far interpolation mechanisms based on the nearest-neighbor rule (NNR) can support cancer research. The main objective is to usethe NNR to predict the likelihood of tumorigenesis based on given risk factors.By using a genetic algorithm to optimize the parameters of the nearest-neighbourprediction, the performance of this interpolation method can be improved sub-stantially. Furthermore, it is possible to detect risk factors which are hardly ornot relevant to tumorigenesis. Our preliminary studies demonstrate that NNR-based interpolation is a simple tool that nevertheless has enough potential to beseriously considered for cancer research or related research.

We present a novel approach to classification, based on a tight coupling of instancebased learning and a genetic algorithm. In contrast to the usual instance-based learning setting, we do not rely on (parts of) the given training set as the basis of a nearestneighbor classifier, but we try to employ artificially generated instances as concept prototypes. The extremely hard problem of finding an appropriate set of concept prototypes is tackled by a genetic search procedure with the classification accuracy on the given training set as evaluation criterion for the genetic fitness measure. Experiments with artificial datasets show that - due to the ability to find concise and accurate concept descriptions that contain few, but typical instances - this classification approach is considerably robust against noise, untypical training instances and irrelevant attributes. These favorable (theoretical) properties are corroborated using a number of hard real-world classification problems.

We present an approach to automating the selection of search-guiding heuris-tics that control the search conducted by a problem solver. The approach centerson representing problems with feature vectors that are vectors of numerical val-ues. Thus, similarity between problems can be determined by using a distancemeasure on feature vectors. Given a database of problems, each problem beingassociated with the heuristic that was used to solve it, heuristics to be employedto solve a novel problem are suggested in correspondence with the similaritybetween the novel problem and problems of the database.Our approach is strongly connected with instance-based learning and nearest-neighbor classification and therefore possesses incremental learning capabilities.In experimental studies it has proven to be a viable tool for achieving the finaland crucial missing piece of automation of problem solving - namely selecting anappropriate search-guiding heuristic - in a flexible way.This work was supported by the Deutsche Forschungsgemeinschaft (DFG).

A method for efficiently handling associativity and commutativity (AC) in implementations of (equational) theorem provers without incorporating AC as an underlying theory will be presented. The key of substantial efficiency gains resides in a more suitable representation of permutation-equations (such as f(x,f(y,z))=f(y,f(z,x)) for instance). By representing these permutation-equations through permutations in the mathematical sense (i.e. bijective func- tions :{1,..,n} {1,..,n}), and by applying adapted and specialized inference rules, we can cope more appropriately with the fact that permutation-equations are playing a particular role. Moreover, a number of restrictions concerning application and generation of permuta- tion-equations can be found that would not be possible in this extent when treating permu- tation-equations just like any other equation. Thus, further improvements in efficiency can be achieved.

We are going to present two methods that allow to exploit previous expe-rience in the area of automated deduction. The first method adapts (learns)the parameters of a heuristic employed for controlling the application of infer-ence rules in order to find a known proof with as little redundant search effortas possible. Adaptation is accomplished by a genetic algorithm. A heuristiclearned that way can then be profitably used to solve similar problems. Thesecond method attempts to re-enact a known proof in a flexible manner in orderto solve an unknown problem whose proof is believed to lie in (close) vicinity.The experimental results obtained with an equational theorem prover show thatthese methods not only allow for impressive speed-ups, but also make it possibleto handle problems that were out of reach before.

Problems stemming from the study of logic calculi in connection with an infer-ence rule called "condensed detachment" are widely acknowledged as prominenttest sets for automated deduction systems and their search guiding heuristics. Itis in the light of these problems that we demonstrate the power of heuristics thatmake use of past proof experience with numerous experiments.We present two such heuristics. The first heuristic attempts to re-enact aproof of a proof problem found in the past in a flexible way in order to find a proofof a similar problem. The second heuristic employs "features" in connection withpast proof experience to prune the search space. Both these heuristics not onlyallow for substantial speed-ups, but also make it possible to prove problems thatwere out of reach when using so-called basic heuristics. Moreover, a combinationof these two heuristics can further increase performance.We compare our results with the results the creators of Otter obtained withthis renowned theorem prover and this way substantiate our achievements.

We present a method for learning heuristics employed by an automated proverto control its inference machine. The hub of the method is the adaptation of theparameters of a heuristic. Adaptation is accomplished by a genetic algorithm.The necessary guidance during the learning process is provided by a proof prob-lem and a proof of it found in the past. The objective of learning consists infinding a parameter configuration that avoids redundant effort w.r.t. this prob-lem and the particular proof of it. A heuristic learned (adapted) this way canthen be applied profitably when searching for a proof of a similar problem. So,our method can be used to train a proof heuristic for a class of similar problems.A number of experiments (with an automated prover for purely equationallogic) show that adapted heuristics are not only able to speed up enormously thesearch for the proof learned during adaptation. They also reduce redundancies inthe search for proofs of similar theorems. This not only results in finding proofsfaster, but also enables the prover to prove theorems it could not handle before.

In this report we present a case study of employing goal-oriented heuristics whenproving equational theorems with the (unfailing) Knut-Bendix completion proce-dure. The theorems are taken from the domain of lattice ordered groups. It will bedemonstrated that goal-oriented (heuristic) criteria for selecting the next critical paircan in many cases significantly reduce the search effort and hence increase per-formance of the proving system considerably. The heuristic, goalADoriented criteriaare on the one hand based on so-called "measures" measuring occurrences andnesting of function symbols, and on the other hand based on matching subterms.We also deal with the property of goal-oriented heuristics to be particularly helpfulin certain stages of a proof. This fact can be addressed by using them in a frame-work for distributed (equational) theorem proving, namely the "teamwork-method".

We present first steps towards fully automated deduction that merely requiresthe user to submit proof problems and pick up results. Essentially, this necessi-tates the automation of the crucial step in the use of a deduction system, namelychoosing and configuring an appropriate search-guiding heuristic. Furthermore,we motivate why learning capabilities are pivotal for satisfactory performance.The infrastructure for automating both the selection of a heuristic and integra-tion of learning are provided in form of an environment embedding the "core"deduction system.We have conducted a case study in connection with a deduction system basedon condensed detachment. Our experiments with a fully automated deductionsystem 'AutoCoDe' have produced remarkable results. We substantiate Au-toCoDe's encouraging achievements with a comparison with the renowned the-orem prover Otter. AutoCoDe outperforms Otter even when assuming veryfavorable conditions for Otter.

Evolving Combinators
(1996)

One of the many abilities that distinguish a mathematician from an auto-mated deduction system is to be able to offer appropriate expressions based onintuition and experience that are substituted for existentially quantified variablesso as to simplify the problem at hand substantially. We propose to simulate thisability with a technique called genetic programming for use in automated deduc-tion. We apply this approach to problems of combinatory logic. Our experimen-tal results show that the approach is viable and actually produces very promisingresults. A comparison with the renowned theorem prover Otter underlines theachievements.This work was supported by the Deutsche Forschungsgemeinschaft (DFG).