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- Fachbereich Mathematik (943) (remove)

In this work a 3-dimensional contact elasticity problem for a thin fiber and a rigid foundation is studied. We describe the contact condition by a linear Robin-condition (by meaning of the penalized and linearized non-penetration and friction conditions).
The dimension of the problem is reduced by an asymptotic approach. Scaling the Robin parameters appropriately we obtain a recurrent chain of Neumann type boundary value problems which are considered only in the microscopic scale. The problem for the leading term is a homogeneous Neumann problem, hence the leading term depends only on the slow variable. This motivates the choice of a multiplicative ansatz in the asymptotic expansion.
The theoretical results are illustrated with numerical examples performed with a commercial finite-element software-tool.

We propose and study a strongly coupled PDE-ODE system with tissue-dependent degenerate diffusion and haptotaxis that can serve as a model prototype for cancer cell invasion through the
extracellular matrix. We prove the global existence of weak solutions and illustrate the model behaviour by numerical simulations for a two-dimensional setting.

We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network
under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features
two interacting cell populations with their mutual transitions and involves tissue-dependent degenerate diffusion and
haptotaxis for the moving subpopulation. The proliferating cells and the tissue evolution are characterized by way of ODEs
for the respective densities. We prove the global existence of weak solutions and illustrate the model behaviour by
numerical simulations in a two-dimensional setting.

The main purpose of the study was to improve the physical properties of the modelling of compressed materials, especially fibrous materials. Fibrous materials are finding increasing application in the industries. And most of the materials are compressed for different applications. For such situation, we are interested in how the fibre arranged, e.g. with which distribution. For given materials it is possible to obtain a three-dimensional image via micro computed tomography. Since some physical parameters, e.g. the fibre lengths or the directions for points in the fibre, can be checked under some other methods from image, it is beneficial to improve the physical properties by changing the parameters in the image.
In this thesis, we present a new maximum-likelihood approach for the estimation of parameters of a parametric distribution on the unit sphere, which is various as some well known distributions, e.g. the von-Mises Fisher distribution or the Watson distribution, and for some models better fit. The consistency and asymptotic normality of the maximum-likelihood estimator are proven. As the second main part of this thesis, a general model of mixtures of these distributions on a hypersphere is discussed. We derive numerical approximations of the parameters in an Expectation Maximization setting. Furthermore we introduce a non-parametric estimation of the EM algorithm for the mixture model. Finally, we present some applications to the statistical analysis of fibre composites.

This thesis is devoted to deal with the stochastic optimization problems in various situations with the aid of the Martingale method. Chapter 2 discusses the Martingale method and its applications to the basic optimization problems, which are well addressed in the literature (for example, [15], [23] and [24]). In Chapter 3, we study the problem of maximizing expected utility of real terminal wealth in the presence of an index bond. Chapter 4, which is a modification of the original research paper joint with Korn and Ewald [39], investigates an optimization problem faced by a DC pension fund manager under inflationary risk. Although the problem is addressed in the context of a pension fund, it presents a way of how to deal with the optimization problem, in the case there is a (positive) endowment. In Chapter 5, we turn to a situation where the additional income, other than the income from returns on investment, is gained by supplying labor. Chapter 6 concerns a situation where the market considered is incomplete. A trick of completing an incomplete market is presented there. The general theory which supports the discussion followed is summarized in the first chapter.

Algebraic Systems Theory
(2004)

Control systems are usually described by differential equations, but their properties of interest are most naturally expressed in terms of the system trajectories, i.e., the set of all solutions to the equations. This is the central idea behind the so-called "behavioral approach" to systems and control theory. On the other hand, the manipulation of linear systems of differential equations can be formalized using algebra, more precisely, module theory and homological methods ("algebraic analysis"). The relationship between modules and systems is very rich, in fact, it is a categorical duality in many cases of practical interest. This leads to algebraic characterizations of structural systems properties such as autonomy, controllability, and observability. The aim of these lecture notes is to investigate this module-system correspondence. Particular emphasis is put on the application areas of one-dimensional rational systems (linear ODE with rational coefficients), and multi-dimensional constant systems (linear PDE with constant coefficients).

These lecture notes give a completely self-contained introduction to the control theory of linear time-invariant systems. No prior knowledge is requried apart from linear algebra and some basic familiarity with ordinary differential equations. Thus, the course is suited for students of mathematics in their second or third year, and for theoretically inclined engineering students. Because of its appealing simplicity and elegance, the behavioral approch has been adopted to a large extend. A short list of recommended text books on the subject has been added, as a suggestion for further reading.

A Topology Primer
(2002)

Manifolds
(2017)

The thesis at hand deals with the numerical solution of multiscale problems arising in the modeling of processes in fluid and thermo dynamics. Many of these processes, governed by partial differential equations, are relevant in engineering, geoscience, and environmental studies. More precisely, this thesis discusses the efficient numerical computation of effective macroscopic thermal conductivity tensors of high-contrast composite materials. The term "high-contrast" refers to large variations in the conductivities of the constituents of the composite. Additionally, this thesis deals with the numerical solution of Brinkman's equations. This system of equations adequately models viscous flows in (highly) permeable media. It was introduced by Brinkman in 1947 to reduce the deviations between the measurements for flows in such media and the predictions according to Darcy's model.

In the first part of the thesis we develop the theory of standard bases in free modules over (localized) polynomial rings. Given that linear equations are solvable in the coefficients of the polynomials, we introduce an algorithm to compute standard bases with respect to arbitrary (module) monomial orderings. Moreover, we take special care to principal ideal rings, allowing zero divisors. For these rings we design modified algorithms which are new and much faster than the general ones. These algorithms were motivated by current limitations in formal verification of microelectronic System-on-Chip designs. We show that our novel approach using computational algebra is able to overcome these limitations in important classes of applications coming from industrial challenges.
The second part is based on research in collaboration with Jason Morton, Bernd Sturmfels and Anne Shiu. We devise a general method to describe and compute a certain class of rank tests motivated by statistics. The class of rank tests may loosely be described as being based on computing the number of linear extensions to given partial orders. In order to apply these tests to actual data we developed two algorithms and used our implementations to apply the methodology to gene expression data created at the Stowers Institute for Medical Research. The dataset is concerned with the development of the vertebra. Our rankings proved valuable to the biologists.

Model uncertainty is a challenge that is inherent in many applications of mathematical models in various areas, for instance in mathematical finance and stochastic control. Optimization procedures in general take place under a particular model. This model, however, might be misspecified due to statistical estimation errors and incomplete information. In that sense, any specified model must be understood as an approximation of the unknown "true" model. Difficulties arise since a strategy which is optimal under the approximating model might perform rather bad in the true model. A natural way to deal with model uncertainty is to consider worst-case optimization.
The optimization problems that we are interested in are utility maximization problems in continuous-time financial markets. It is well known that drift parameters in such markets are notoriously difficult to estimate. To obtain strategies that are robust with respect to a possible misspecification of the drift we consider a worst-case utility maximization problem with ellipsoidal uncertainty sets for the drift parameter and with a constraint on the strategies that prevents a pure bond investment.
By a dual approach we derive an explicit representation of the optimal strategy and prove a minimax theorem. This enables us to show that the optimal strategy converges to a generalized uniform diversification strategy as uncertainty increases.
To come up with a reasonable uncertainty set, investors can use filtering techniques to estimate the drift of asset returns based on return observations as well as external sources of information, so-called expert opinions. In a Black-Scholes type financial market with a Gaussian drift process we investigate the asymptotic behavior of the filter as the frequency of expert opinions tends to infinity. We derive limit theorems stating that the information obtained from observing the discrete-time expert opinions is asymptotically the same as that from observing a certain diffusion process which can be interpreted as a continuous-time expert. Our convergence results carry over to convergence of the value function in a portfolio optimization problem with logarithmic utility.
Lastly, we use our observations about how expert opinions improve drift estimates for our robust utility maximization problem. We show that our duality approach carries over to a financial market with non-constant drift and time-dependence in the uncertainty set. A time-dependent uncertainty set can then be defined based on a generic filter. We apply this to various investor filtrations and investigate which effect expert opinions have on the robust strategies.

In this dissertation we consider complex, projective hypersurfaces with many isolated singularities. The leading questions concern the maximal number of prescribed singularities of such hypersurfaces in a given linear system, and geometric properties of the equisingular stratum. In the first part a systematic introduction to the theory of equianalytic families of hypersurfaces is given. Furthermore, the patchworking method for constructing hypersurfaces with singularities of prescribed types is described. In the second part we present new existence results for hypersurfaces with many singularities. Using the patchworking method, we show asymptotically proper results for hypersurfaces in P^n with singularities of corank less than two. In the case of simple singularities, the results are even asymptotically optimal. These statements improve all previous general existence results for hypersurfaces with these singularities. Moreover, the results are also transferred to hypersurfaces defined over the real numbers. The last part of the dissertation deals with the Castelnuovo function for studying the cohomology of ideal sheaves of zero-dimensional schemes. Parts of the theory of this function for schemes in P^2 are generalized to the case of schemes on general surfaces in P^3. As an application we show an H^1-vanishing theorem for such schemes.

Sudakov's typical marginals, random linear functionals and a conditional central limit theorem
(1997)

V.N. Sudakov [Sud78] proved that the one-dimensional marginals of a highdimensional second order measure are close to each other in most directions. Extending this and a related result in the context of projection pursuit of P. Diaconis and D. Freedman [Dia84], we give for a probability measure P and a random (a.s.) linear functional F on a Hilbert space simple sufficient conditions under which most of the one-dimensional images of P under F are close to their canonical mixture which turns out to be almost a mixed normal distribution. Using the concept of approximate conditioning we deduce a conditional central limit theorem (theorem 3) for random averages of triangular arrays of random variables which satisfy only fairly weak asymptotic orthogonality conditions.

Starting from the uniqueness question for mixtures of distributions this review centers around the question under which formally weaker assumptions one can prove the existence of SPLIFs, in other words perfect statistics and tests. We mention a couple of positive and negative results which complement the basic contribution of David Blackwell in 1980. Typically the answers depend on the choice of the set theoretic axioms and on the particular concepts of measurability.

We study a model for learning periodic signals in recurrent neural networks proposed by Doya and Yoshizawa [7] that can be considered as a model for temporal pattern memory in animal motoric systems. A network receives an external oscillatory input and adjusts its weights so that this signal can be reproduced approximately as the network output after some time. We use tools from adaptive control theory to derive an algorithm for weight matrices with special structure. If the input is generated by a network of the same structure the algorithm converges globally and does not exhibit the deficiencies of the back-propagation based approach of Doya and Yoshizawa under a persistency of excitation condition. This simple algorithm can also be used for open loop identification under quite restructive assumptions. The persistency of excitation condition cannot be proven even for the matrices with special structure but for a 3d system. For higher dimensional systems we give connections to the theory of linear time-varying systems where this condition is generically true (under assumption which are also needed in the time-invariant case). However, we cannot show that the linearized system related to the nonlinear neural network fulfills these generic assumptions.

The edge enhancement property of a nonlinear diffusion equation with a suitable expression for the diffusivity is an important feature for image processing. We present an algorithm to solve this equation in a wavelet basis and discuss its one dimensional version in some detail. Sample calculations demonstrate principle effects and treat in particular the case of highly noise perturbed signals. The results are discussed with respect to performance, efficiency, choice of parameters and are illustrated by a large number of figures. Finally, a comparison with a Fourier method and a finite volume method is performed.

Cloudy inhomogenities in artificial fabrics are graded by a fast method which is based on a Laplacian pyramid decomposition of the fabric image. This band-pass representation takes into account the scale character of the cloudiness. A quality measure of the entire cloudiness is obtained as a weighted mean over the variances of all scales.

The ideas of texture analysis by means of the structure tensor are combined with the scale-space concept of anisotropic diffusion filtering. In contrast to many other nonlinear diffusion techniques, the proposed one uses a diffusion tensor instead of a scalar diffusivity. This allows true anisotropic behaviour. The preferred diffusion direction is determined according to the phase angle of the structure tensor. The diffusivity in this direction is increasing with the local coherence of the signal. This filter is constructed in such a way that it gives a mathematically well-funded scale-space representation of the original image. Experiments demonstrate its usefulness for the processing of interrupted one-dimensional structures such as fingerprint and fabric images.

A survey on continuous, semidiscrete and discrete well-posedness and scale-space results for a class of nonlinear diffusion filters is presented. This class does not require any monotony assumption (comparison principle) and, thus, allows image restoration as well. The theoretical results include existence, uniqueness, continuous dependence on the initial image, maximum-minimum principles, average grey level invariance, smoothing Lyapunov functionals, and convergence to a constant steady state.

The performance of napkins is nowadays improved substantially by embedding granules of a superabsorbent into the cellulose matrix. In this paper a continuous model for the liquid transport in such an Ultra Napkin is proposed. Its mean feature is a nonlinear diffusion equation strongly coupled with an ODE describing a reversible absorbtion process. An efficient numerical method based on a symmetrical time splitting and a finite difference scheme of ADI-predictor-corrector type has been developed to solve these equations in a three dimensional setting. Numerical results are presented that can be used to optimize the granule distribution.

In spite of its lack of theoretical justification, nonlinear diffusion filtering has become a powerful image enhancement tool in the recent years. The goal of the present paper is to provide a mathematical foundation for nonlinear diffusion filtering as a scale-space transformation which is flexible enough to simplify images without loosing the capability of enhancing edges. By stuying the Lyapunow functional, it is shown that nonlinear diffusion reduces Lp norms and central moments and increases the entropy of images. The proposed anisotropic class utilizes a diffusion tensor which may be adapted to the image structure. It permits existence, uniqueness and regularity results, the solution depends continuously on the initial image, and it fulfills an extremum principle. All considerations include linear and certain nonlinear isotropic models and apply to m-dimensional vector-valued images. The results are juxtaposed to linear and morphological scale-spaces.

A way to derive consistently kinetic models for vehicular traffic from microscopic follow the leader models is presented. The obtained class of kinetic equations is investigated. Explicit examples for kinetic models are developed with a particular emphasis on obtaining models, that give realistic results. For space homogeneous traffic flow situations numerical examples are given including stationary distributions and fundamental diagrams.

In this paper we present a method for nonlinear frequency response analysis of mechanical vibrations of 3-dimensional solid structures.
For computing nonlinear frequency response to periodic excitations, we employ the well-established harmonic balance method.
A fundamental aspect for allowing a large-scale application of the method is model order reduction of the discretized equation of motion. Therefore we propose the utilization of a modal projection method enhanced with modal derivatives, providing second-order information.
For an efficient spatial discretization of continuum mechanics nonlinear partial differential equations, including large deformations and hyperelastic material laws, we use the isogeometric finite element method, which has already been shown to possess advantages over classical finite element discretizations in terms of higher accuracy of numerical approximations in the fields of linear vibration and static large deformation analysis.
With several computational examples, we demonstrate the applicability and accuracy of the modal derivative reduction method for nonlinear static computations and vibration analysis.
Thus, the presented method opens a promising perspective on application of nonlinear frequency analysis to large-scale industrial problems.

In this paper we analyze the vibrations of nonlinear structures by means of the novel approach of isogeometric finite elements. The fundamental idea of isogeometric finite elements is to apply the same functions, namely B-Splines and NURBS (Non-Uniform Rational B-Splines), for describing the geometry and for representing the numerical solution. In case of linear vibrational analysis, this approach has already been shown to possess substantial advantages over classical finite elements, and we extend it here to a nonlinear framework based on the harmonic balance principle.
As application, the straight nonlinear Euler-Bernoulli beam is used, and overall, it is demonstrated that isogeometric finite elements with B-Splines in combination with the harmonic balance method are a powerful means for the analysis of nonlinear structural vibrations. In particular, the smoother k-method provides higher accuracy than the p-method for isogeometric nonlinear vibration analysis.

In this thesis we present a new method for nonlinear frequency response analysis of mechanical vibrations.
For an efficient spatial discretization of nonlinear partial differential equations of continuum mechanics we employ the concept of isogeometric analysis. Isogeometric finite element methods have already been shown to possess advantages over classical finite element discretizations in terms of exact geometry representation and higher accuracy of numerical approximations using spline functions.
For computing nonlinear frequency response to periodic external excitations, we rely on the well-established harmonic balance method. It expands the solution of the nonlinear ordinary differential equation system resulting from spatial discretization as a truncated Fourier series in the frequency domain.
A fundamental aspect for enabling large-scale and industrial application of the method is model order reduction of the spatial discretization of the equation of motion. Therefore we propose the utilization of a modal projection method enhanced with modal derivatives, providing second-order information. We investigate the concept of modal derivatives theoretically and using computational examples we demonstrate the applicability and accuracy of the reduction method for nonlinear static computations and vibration analysis.
Furthermore, we extend nonlinear vibration analysis to incompressible elasticity using isogeometric mixed finite element methods.

The efficient numerical treatment of the Boltzmann equation is a very important task in many fields of application. Most of the practically relevant numerical schemes are based on the simulation of large particle systems that approximate the evolution of the distribution function described by the Boltzmann equation. In particular, stochastic particle systems play an important role in the construction of various numerical algorithms.

In this text we survey some large deviation results for diffusion processes. The first chapters present results from the literature such as the Freidlin-Wentzell theorem for diffusions with small noise. We use these results to prove a new large deviation theorem about diffusion processes with strong drift. This is the main result of the thesis. In the later chapters we give another application of large deviation results, namely to determine the exponential decay rate for the Bayes risk when separating two different processes. The final chapter presents techniques which help to experiment with rare events for diffusion processes by means of computer simulations.

In this thesis we explicitly solve several portfolio optimization problems in a very realistic setting. The fundamental assumptions on the market setting are motivated by practical experience and the resulting optimal strategies are challenged in numerical simulations.
We consider an investor who wants to maximize expected utility of terminal wealth by trading in a high-dimensional financial market with one riskless asset and several stocks.
The stock returns are driven by a Brownian motion and their drift is modelled by a Gaussian random variable. We consider a partial information setting, where the drift is unknown to the investor and has to be estimated from the observable stock prices in addition to some analyst’s opinion as proposed in [CLMZ06]. The best estimate given these observations is the well known Kalman-Bucy-Filter. We then consider an innovations process to transform the partial information setting into a market with complete information and an observable Gaussian drift process.
The investor is restricted to portfolio strategies satisfying several convex constraints.
These constraints can be due to legal restrictions, due to fund design or due to client's specifications. We cover in particular no-short-selling and no-borrowing constraints.
One popular approach to constrained portfolio optimization is the convex duality approach of Cvitanic and Karatzas. In [CK92] they introduce auxiliary stock markets with shifted market parameters and obtain a dual problem to the original portfolio optimization problem that can be better solvable than the primal problem.
Hence we consider this duality approach and using stochastic control methods we first solve the dual problems in the cases of logarithmic and power utility.
Here we apply a reverse separation approach in order to obtain areas where the corresponding Hamilton-Jacobi-Bellman differential equation can be solved. It turns out that these areas have a straightforward interpretation in terms of the resulting portfolio strategy. The areas differ between active and passive stocks, where active stocks are invested in, while passive stocks are not.
Afterwards we solve the auxiliary market given the optimal dual processes in a more general setting, allowing for various market settings and various dual processes.
We obtain explicit analytical formulas for the optimal portfolio policies and provide an algorithm that determines the correct formula for the optimal strategy in any case.
We also show optimality of our resulting portfolio strategies in different verification theorems.
Subsequently we challenge our theoretical results in a historical and an artificial simulation that are even closer to the real world market than the setting we used to derive our theoretical results. However, we still obtain compelling results indicating that our optimal strategies can outperform any benchmark in a real market in general.

If \(A\) generates a bounded cosine function on a Banach space \(X\) then the negative square root \(B\) of \(A\) generates a holomorphic semigroup, and this semigroup is the conjugate potential transform of the cosine function. This connection is studied in detail, and it is used for a characterization of cosine function generators in terms of growth conditions on the semigroup generated by \(B\). This characterization relies on new results on the inversion of the vector-valued conjugate potential transform.

Let \(X\) be a Banach lattice. Necessary and sufficient conditions for a linear operator \(A:D(A) \to X\), \(D(A)\subseteq X\), to be of positive \(C^0\)-scalar type are given. In addition, the question is discussed which conditions on the Banach lattice imply that every operator of positive \(C^0\)-scalar type is necessarily of positive scalar type.

In the scalar case one knows that a complex normalized function of boundedvariation \(\phi\) on \([0,1]\) defines a unique complex regular Borel measure\(\mu\) on \([0,1]\). In this note we show that this is no longer true in generalin the vector valued case, even if \(\phi\) is assumed to be continuous. Moreover, the functions \(\phi\) which determine a countably additive vectormeasure \(\mu\) are characterized.

\(C^0\)-scalar-type spectrality criterions for operators \(A\), whose resolvent set contains the negative reals, are provided. The criterions are given in terms of growth conditions on the resolvent of \(A\) and the semi-group generated by \(A\).These criterions characterize scalar-type operators on the Banach space \(X\), if and only if \(X\) has no subspace isomorphic to the space of complex null-sequences.

The following two norms for holomorphic functions \(F\), defined on the right complex half-plane \(\{z \in C:\Re(z)\gt 0\}\) with values in a Banach space \(X\), are equivalent:
\[\begin{eqnarray*} \lVert F \rVert _{H_p(C_+)} &=& \sup_{a\gt0}\left( \int_{-\infty}^\infty \lVert F(a+ib) \rVert ^p \ db \right)^{1/p}
\mbox{, and} \\ \lVert F \rVert_{H_p(\Sigma_{\pi/2})} &=& \sup_{\lvert \theta \lvert \lt \pi/2}\left( \int_0^\infty \left \lVert F(re^{i \theta}) \right \rVert ^p\ dr \right)^{1/p}.\end{eqnarray*}\] As a consequence, we derive a description of boundary values ofsectorial holomorphic functions, and a theorem of Paley-Wiener typefor sectorial holomorphic functions.

In the Banach space co there exists a continuous function of bounded semivariation which does not correspond to a countably additive vector measure. This result is in contrast to the scalar case, and it has consequences for the characterization of scalar-type operators. Besides this negative result we introduce the notion of functions of unconditionally bounded variation which are exactly the generators of countably additive vector measures.

The thermal equilibrium state of a bipolar, isothermal quantum fluid confined to a bounded domain \(\Omega\subset I\!\!R^d,d=1,2\) or \( d=3\) is the minimizer of the total energy \({\mathcal E}_{\epsilon\lambda}\); \({\mathcal E}_{\epsilon\lambda}\) involves the squares of the scaled Planck's constant \(\epsilon\) and the scaled minimal Debye length \(\lambda\). In applications one frequently has \(\lambda^2\ll 1\). In these cases the zero-space-charge approximation is rigorously justified. As \(\lambda \to 0 \), the particle densities converge to the minimizer of a limiting quantum zero-space-charge functional exactly in those cases where the doping profile satisfies some compatibility conditions. Under natural additional assumptions on the internal energies one gets an differential-algebraic system for the limiting \((\lambda=0)\) particle densities, namely the quantum zero-space-charge model. The analysis of the subsequent limit \(\epsilon \to 0\) exhibits the importance of quantum gaps. The semiclassical zero-space-charge model is, for small \(\epsilon\), a reasonable approximation of the quantum model if and only if the quantum gap vanishes. The simultaneous limit \(\epsilon =\lambda \to 0\) is analyzed.

Cell migration is essential for embryogenesis, wound healing, immune surveillance, and
progression of diseases, such as cancer metastasis. For the migration to occur, cellular
structures such as actomyosin cables and cell-substrate adhesion clusters must interact.
As cell trajectories exhibit a random character, so must such interactions. Furthermore,
migration often occurs in a crowded environment, where the collision outcome is deter-
mined by altered regulation of the aforementioned structures. In this work, guided by a
few fundamental attributes of cell motility, we construct a minimal stochastic cell migration
model from ground-up. The resulting model couples a deterministic actomyosin contrac-
tility mechanism with stochastic cell-substrate adhesion kinetics, and yields a well-defined
piecewise deterministic process. The signaling pathways regulating the contractility and
adhesion are considered as well. The model is extended to include cell collectives. Numer-
ical simulations of single cell migration reproduce several experimentally observed results,
including anomalous diffusion, tactic migration, and contact guidance. The simulations
of colliding cells explain the observed outcomes in terms of contact induced modification
of contractility and adhesion dynamics. These explained outcomes include modulation
of collision response and group behavior in the presence of an external signal, as well as
invasive and dispersive migration. Moreover, from the single cell model we deduce a pop-
ulation scale formulation for the migration of non-interacting cells. In this formulation,
the relationships concerning actomyosin contractility and adhesion clusters are maintained.
Thus, we construct a multiscale description of cell migration, whereby single, collective,
and population scale formulations are deduced from the relationships on the subcellular
level in a mathematically consistent way.

Universal Shortest Paths
(2010)

We introduce the universal shortest path problem (Univ-SPP) which generalizes both - classical and new - shortest path problems. Starting with the definition of the even more general universal combinatorial optimization problem (Univ-COP), we show that a variety of objective functions for general combinatorial problems can be modeled if all feasible solutions have the same cardinality. Since this assumption is, in general, not satisfied when considering shortest paths, we give two alternative definitions for Univ-SPP, one based on a sequence of cardinality contrained subproblems, the other using an auxiliary construction to establish uniform length for all paths between source and sink. Both alternatives are shown to be (strongly) NP-hard and they can be formulated as quadratic integer or mixed integer linear programs. On graphs with specific assumptions on edge costs and path lengths, the second version of Univ-SPP can be solved as classical sum shortest path problem.

It is well known that the greedy algorithm solves matroid base problems for all linear cost functions and is, in fact, correct if and only if the underlying combinatorial structure of the problem is a matroid. Moreover, the algorithm can be applied to problems with sum, bottleneck, algebraic sum or \(k\)-sum objective functions.

The shortest path problem in which the \((s,t)\)-paths \(P\) of a given digraph \(G =(V,E)\) are compared with respect to the sum of their edge costs is one of the best known problems in combinatorial optimization. The paper is concerned with a number of variations of this problem having different objective functions like bottleneck, balanced, minimum deviation, algebraic sum, \(k\)-sum and \(k\)-max objectives, \((k_1, k_2)-max, (k_1, k_2)\)-balanced and several types of trimmed-mean objectives. We give a survey on existing algorithms and propose a general model for those problems not yet treated in literature. The latter is based on the solution of resource constrained shortest path problems with equality constraints which can be solved in pseudo-polynomial time if the given graph is acyclic and the number of resources is fixed. In our setting, however, these problems can be solved in strongly polynomial time. Combining this with known results on \(k\)-sum and \(k\)-max optimization for general combinatorial problems, we obtain strongly polynomial algorithms for a variety of path problems on acyclic and general digraphs.

Laser-induced thermotherapy (LITT) is an established minimally invasive percutaneous technique of tumor ablation. Nevertheless, there is a need to predict the effect of laser applications and optimizing irradiation planning in LITT. Optical attributes (absorption, scattering) change due to thermal denaturation. The work presents the possibility to identify these temperature dependent parameters from given temperature measurements via an optimal control problem. The solvability of the optimal control problem is analyzed and results of successful implementations are shown.

This thesis focuses on dealing with some new aspects of continuous time portfolio optimization by using the stochastic control method.
First, we extend the Busch-Korn-Seifried model for a large investor by using the Vasicek model for the short rate, and that problem is solved explicitly for two types of intensity functions.
Next, we justify the existence of the constant proportion portfolio insurance (CPPI) strategy in a framework containing a stochastic short rate and a Markov switching parameter. The effect of Vasicek short rate on the CPPI strategy has been studied by Horsky (2012). This part of the thesis extends his research by including a Markov switching parameter, and the generalization is based on the B\"{a}uerle-Rieder investment problem. The explicit solutions are obtained for the portfolio problem without the Money Market Account as well as the portfolio problem with the Money Market Account.
Finally, we apply the method used in Busch-Korn-Seifried investment problem to explicitly solve the portfolio optimization with a stochastic benchmark.