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We consider a variant of a knapsack problem with a fixed cardinality constraint. There are three objective functions to be optimized: one real-valued and two integer-valued objectives. We show that this problem can be solved efficiently by a local search. The algorithm utilizes connectedness of a subset of feasible solutions and has optimal run-time.

Inverse treatment planning of intensity modulated radiothrapy is a multicriteria optimization problem: planners have to find optimal compromises between a sufficiently high dose in tumor tissue that garantuee a high tumor control, and, dangerous overdosing of critical structures, in order to avoid high normal tissue complcication problems. The approach presented in this work demonstrates how to state a flexible generic multicriteria model of the IMRT planning problem and how to produce clinically highly relevant Pareto-solutions. The model is imbedded in a principal concept of Reverse Engineering, a general optimization paradigm for design problems. Relevant parts of the Pareto-set are approximated by using extreme compromises as cornerstone solutions, a concept that is always feasible if box constraints for objective funtions are available. A major practical drawback of generic multicriteria concepts trying to compute or approximate parts of the Pareto-set is the high computational effort. This problem can be overcome by exploitation of an inherent asymmetry of the IMRT planning problem and an adaptive approximation scheme for optimal solutions based on an adaptive clustering preprocessing technique. Finally, a coherent approach for calculating and selecting solutions in a real-timeinteractive decision-making process is presented. The paper is concluded with clinical examples and a discussion of ongoing research topics.

Multicriteria Optimization
(1999)

Life is about decisions. Decisions, no matter if taken by a group or an individual, involve several conflicting objectives. The observation that real world problems have to be solved optimally according to criteria, which prohibit an "ideal" solution - optimal for each decisionmaker under each of the criteria considered - , has led to the development of multicriteria optimization. From its first roots, which where laid by Pareto at the end of the 19th century the discilpine has prospered and grown, especially during the last three decades. Today, many decision support systems incorporate methods to deal with conflicting objectives. The foundation for such systems is a mathematical theory of optimaztion under multiple objectives. With this manuscript, which is based on lectures I taught in the winter semester 1998/99 at the University of Kaiserslautern, I intend to give an introduction to and overview of this fascinating field of mathematics. I tried to present theoretical questions such as existence of solutions as well as methodological issues and hope the reader finds the balance not too heavily on one side. The interested reader should be able to find classical results as well as up to date research. The text is accompanied by exercises, which hopefully help to deepen students' understanding of the topic.