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Wed, 18 Jun 2008 15:27:35 +0200Wed, 18 Jun 2008 15:27:35 +0200Determination of interaction between MCT1 and CAII via a mathematical and physiological approach
https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1991
The enzyme carbonic anhydrase isoform II (CAII), catalysing the hydration and dehydration of CO2, enhances transport activity of the monocarboxylate transporter isoform I (MCT1, SLC16A1) expressed in Xenopus oocytes by a mechanism that does not require CAII catalytic activity (Becker et al. (2005) J. Biol. Chem., 280). In the present study, we have investigated the mechanism of the CAII induced increase in transport activity by using electrophysiological techniques and a mathematical model of the MCT1 transport cycle. The model consists of six states arranged in cyclic fashion and features an ordered, mirror-symmetric, binding mechanism were binding and unbinding of the proton to the transport protein is considered to be the rate limiting step under physiological conditions. An explicit rate expression for the substrate °ux is derived using model reduction techniques. By treating the pools of intra- and extracellular MCT1 substrates as dynamic states, the time dependent kinetics are obtained by integration using the derived expression for the substrate °ux. The simulations were compared with experimental data obtained from MCT1-expressing oocytes injected with di®erent amounts of CAII. The model suggests that CAII increases the e®ective rate constants of the proton reactions, possibly by working as a proton antenna.J. Almquist; H. Schmidt; P. Lang; J. Deitmer; M. Jirstrand; D. Prätzel-Wolters; H. Beckerreporthttps://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1991Wed, 18 Jun 2008 15:27:35 +0200Diagnosis aiding in Regulation Thermography using Fuzzy Logic
https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1514
The objective of the present article is to give an overview of an application of Fuzzy Logic in Regulation Thermography, a method of medical diagnosis support. An introduction to this method of the complementary medical science based on temperature measurements – so-called thermograms – is provided. The process of modelling the physician’s thermogram evaluation rules using the calculus of Fuzzy Logic is explained.H. Knaf; P. Lang; Zeiser. S.reporthttps://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1514Tue, 10 Feb 2004 10:16:26 +0100Blocked neural networks for knowledge extraction in the software development process
https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1513
One of the main goals of an organization developing software is to increase the quality of the software while at the same time to decrease the costs and the duration of the development process. To achieve this, various decisions e.ecting this goal before and during the development process have to be made by the managers. One appropriate tool for decision support are simulation models of the software life cycle, which also help to understand the dynamics of the software development process. Building up a simulation model requires a mathematical description of the interactions between di.erent objects involved in the development process. Based on experimental data, techniques from the .eld of knowledge discovery can be used to quantify these interactions and to generate new process knowledge based on the analysis of the determined relationships. In this paper blocked neuronal networks and related relevance measures will be presented as an appropriate tool for quanti.cation and validation of qualitatively known dependencies in the software development process.P. Lang; A. Sarishvili; A. Wirsenreporthttps://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1513Tue, 10 Feb 2004 10:15:28 +0100Padé-like reduction of stable discrete linear systems preserving their stability
https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1505
A new stability preserving model reduction algorithm for discrete linear SISO-systems based on their impulse response is proposed. Similar to the Padé approximation, an equation system for the Markov parameters involving the Hankel matrix is considered, that here however is chosen to be of very high dimension. Although this equation system therefore in general cannot be solved exactly, it is proved that the approximate solution, computed via the Moore-Penrose inverse, gives rise to a stability preserving reduction scheme, a property that cannot be guaranteed for the Padé approach. Furthermore, the proposed algorithm is compared to another stability preserving reduction approach, namely the balanced truncation method, showing comparable performance of the reduced systems. The balanced truncation method however starts from a state space description of the systems and in general is expected to be more computational demanding.S. Feldmann; P. Langreporthttps://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1505Tue, 10 Feb 2004 10:01:35 +0100Parameter Influence On The Zeros Of NetworkDeterminants
https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1489
To a network N(q) with determinant D(s;q) depending on a parameter vector q Î Rr via identification of some of its vertices, a network N^ (q) is assigned. The paper deals with procedures to find N^ (q), such that its determinant D^ (s;q) admits a factorization in the determinants of appropriate subnetworks, and with the estimation of the deviation of the zeros of D^ from the zeros of D. To solve the estimation problem state space methods are applied.S. Feldmann; P. Lang; D. Prätzel-Woltersreporthttps://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/1489Mon, 02 Feb 2004 15:32:43 +0100