Calorische Restriktion und Lebenserwartung - Ein mathematisches Modell
- Caloric Restriction (CR) is the only intervention proven to retard aging and extend maximum lifespan in mammalians. A possible mechanism for the beneficial effects of CR is that the mild metabolic stress associated with CR induces cells to express stress proteins that increase their resistance to disease processes. In this article we therefore model the retardation of aging by dietary restriction within a mathematical framework. The resulting model comprises food intake, stress proteins, body growth and survival. We successfully applied our model to growth and survival data of mice exposed to different food levels.
Author: | Joachim Türk |
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URN: | urn:nbn:de:hbz:386-kluedo-13570 |
Series (Serial Number): | Preprints (rote Reihe) des Fachbereich Mathematik (339) |
Document Type: | Preprint |
Language of publication: | German |
Year of Completion: | 2004 |
Year of first Publication: | 2004 |
Publishing Institution: | Technische Universität Kaiserslautern |
Date of the Publication (Server): | 2004/12/10 |
Faculties / Organisational entities: | Kaiserslautern - Fachbereich Mathematik |
DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 510 Mathematik |
Licence (German): | Standard gemäß KLUEDO-Leitlinien vor dem 27.05.2011 |