IMRT planning on adaptive volume structures – a significant advance of computational complexity
- In intensity-modulated radiotherapy (IMRT) planning the oncologist faces the challenging task of finding a treatment plan that he considers to be an ideal compromise of the inherently contradictive goals of delivering a sufficiently high dose to the target while widely sparing critical structures. The search for this a priori unknown compromise typically requires the computation of several plans, i.e. the solution of several optimization problems. This accumulates to a high computational expense due to the large scale of these problems - a consequence of the discrete problem formulation. This paper presents the adaptive clustering method as a new algorithmic concept to overcome these difficulties. The computations are performed on an individually adapted structure of voxel clusters rather than on the original voxels leading to a decisively reduced computational complexity as numerical examples on real clinical data demonstrate. In contrast to many other similar concepts, the typical trade-off between a reduction in computational complexity and a loss in exactness can be avoided: the adaptive clustering method produces the optimum of the original problem. This flexible method can be applied to both single- and multi-criteria optimization methods based on most of the convex evaluation functions used in practice
Author: | A. Scherrer, K.-H. Küfer, M. Monz, F. Alonso, T. Bortfeld |
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URN: | urn:nbn:de:hbz:386-kluedo-13400 |
Series (Serial Number): | Berichte des Fraunhofer-Instituts für Techno- und Wirtschaftsmathematik (ITWM Report) (60) |
Document Type: | Report |
Language of publication: | English |
Year of Completion: | 2004 |
Year of first Publication: | 2004 |
Publishing Institution: | Fraunhofer-Institut für Techno- und Wirtschaftsmathematik |
Date of the Publication (Server): | 2004/07/26 |
Tag: | IMRT planning on adaptive volume structures – a significant advance of computational complexity |
Faculties / Organisational entities: | Fraunhofer (ITWM) |
DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 510 Mathematik |
Licence (German): | Standard gemäß KLUEDO-Leitlinien vor dem 27.05.2011 |