Novel Gold Nanoparticles for Dipeptide Recognition in Water
- This work introduces a promising concept for the preparation of new nano-sized receptors. Mixed monolayer protected gold nanoparticles (AuNPs) for low molecular weight compounds were prepared featuring functional groups on their surfaces. It has been shown that these AuNPs can engage in interactions with peptides in aqueous media. Quantitative binding information was obtained from DOSY-NMR titrations indicating that nanoparticles containing a combination of three orthogonal functional groups are more efficient in binding to dipeptides than mono or difunctionalised analogues. The strategy is highly modular and easily allows adapting the receptor selectivity to a given substrate by varying the type, number, and ratio of binding sites on the nanoparticle surface.
Author: | Serap Yapar |
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URN: | urn:nbn:de:hbz:386-kluedo-45041 |
Advisor: | Stefan Kubik |
Document Type: | Doctoral Thesis |
Language of publication: | English |
Date of Publication (online): | 2016/12/06 |
Year of first Publication: | 2016 |
Publishing Institution: | Technische Universität Kaiserslautern |
Granting Institution: | Technische Universität Kaiserslautern |
Acceptance Date of the Thesis: | 2016/09/13 |
Date of the Publication (Server): | 2016/12/12 |
GND Keyword: | Gold nanoparticles; Recognition; Water; Dipeptide; DOSY |
Page Number: | IV, 136 |
Faculties / Organisational entities: | Kaiserslautern - Fachbereich Chemie |
DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 540 Chemie |
Licence (German): | Standard gemäß KLUEDO-Leitlinien vom 30.07.2015 |