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Calorische Restriktion und Lebenserwartung - Ein mathematisches Modell

  • Caloric Restriction (CR) is the only intervention proven to retard aging and extend maximum lifespan in mammalians. A possible mechanism for the beneficial effects of CR is that the mild metabolic stress associated with CR induces cells to express stress proteins that increase their resistance to disease processes. In this article we therefore model the retardation of aging by dietary restriction within a mathematical framework. The resulting model comprises food intake, stress proteins, body growth and survival. We successfully applied our model to growth and survival data of mice exposed to different food levels.

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Author:Joachim Türk
URN (permanent link):urn:nbn:de:hbz:386-kluedo-13570
Serie (Series number):Preprints (rote Reihe) des Fachbereich Mathematik (339)
Document Type:Preprint
Language of publication:German
Year of Completion:2004
Year of Publication:2004
Publishing Institute:Technische Universität Kaiserslautern
Date of the Publication (Server):2004/12/10
Faculties / Organisational entities:Fachbereich Mathematik
DDC-Cassification:5 Naturwissenschaften und Mathematik / 510 Mathematik
Licence (German):Standard gemäß KLUEDO-Leitlinien vor dem 27.05.2011