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Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

  • Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional energetic substrate, which is shuttled between glycolytic and oxidative cells, both under hypoxic and normoxic conditions. Transport of lactate across the cell membrane is mediated by monocarboxylate transporters (MCTs) in cotransport with H+, which is a substrate, a signal and a modulator of metabolic processes. MCTs form a “transport metabolon” with carbonic anhydrases (CAs), which not only provide a rapid equilibrium between CO2, HCO3– and H+, but, in addition, enhances lactate transport, as found in Xenopus oocytes, employed as heterologous expression system, as well as in astrocytes and cancer cells. Functional interactions between different CA isoforms and MCTs have been found to be isoform-specific, independent of the enzyme’s catalytic activity, and they require physical interaction between the proteins. CAs mediate between different states of metabolic acidosis, induced by glycolysis and oxidative phosphorylation, and play a relay function in coupling pH regulation and metabolism. In the brain, metabolic processes in astrocytes appear to be linked to bicarbonate transport and to neuronal activity. Here, we focus on physiological processes of energy dynamics in astrocytes as well as on the transfer of energetic substrates to neurons.
Metadaten
Author:Joachim W. DeitmerORCiD, Shefeeq M. Theparambil, Ivan Ruminot, Sina I. Noor, Holger M. Becker
URN (permanent link):urn:nbn:de:hbz:386-kluedo-58737
ISSN:1662-453X
Parent Title (English):Frontiers in Neuroscience
Publisher:Frontiers
Document Type:Article
Language of publication:English
Publication Date:2019/12/06
Year of Publication:2019
Publishing Institute:Technische Universität Kaiserslautern
Date of the Publication (Server):2020/01/28
Issue:13.2019
Number of page:7
Source:https://www.frontiersin.org/articles/10.3389/fnins.2019.01301/full
Faculties / Organisational entities:Fachbereich Biologie
DDC-Cassification:5 Naturwissenschaften und Mathematik / 590 Tiere (Zoologie)
Collections:Open-Access-Publikationsfonds
Licence (German):Zweitveröffentlichung