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Efficient algorithms for Asymmetric Flow Field Flow Fractionation

  • This thesis is devoted to the modeling and simulation of Asymmetric Flow Field Flow Fractionation, which is a technique for separating particles of submicron scale. This process is a part of large family of Field Flow Fractionation techniques and has a very broad range of industrial applications, e. g. in microbiology, chemistry, pharmaceutics, environmental analysis. Mathematical modeling is crucial for this process, as due to the own nature of the process, lab ex- periments are difficult and expensive to perform. On the other hand, there are several challenges for the mathematical modeling: huge dominance (up to 106 times) of the flow over the diffusion, highly stretched geometry of the device. This work is devoted to developing fast and efficient algorithms, which take into the account the challenges, posed by the application, and provide reliable approximations for the quantities of interest. We present a new Multilevel Monte Carlo method for estimating the distribution functions on a compact interval, which are of the main interest for Asymmetric Flow Field Flow Fractionation. Error estimates for this method in terms of computational cost are also derived. We optimize the flow control at the Focusing stage under the given constraints on the flow and present an important ingredients for the further optimization, such as two-grid Reduced Basis method, specially adapted for the Finite Volume discretization approach.

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Author:Tigran Nagapetyan
URN (permanent link):urn:nbn:de:hbz:386-kluedo-38116
Advisor:Oleg Iliev
Document Type:Doctoral Thesis
Language of publication:English
Publication Date:2014/03/06
Year of Publication:2014
Publishing Institute:Technische Universität Kaiserslautern
Granting Institute:Technische Universität Kaiserslautern
Acceptance Date of the Thesis:2013/11/02
Date of the Publication (Server):2014/06/04
Number of page:VIII, 104 S.
Faculties / Organisational entities:Fachbereich Mathematik
DDC-Cassification:5 Naturwissenschaften und Mathematik / 510 Mathematik
Licence (German):Standard gemäß KLUEDO-Leitlinien vom 10.09.2012