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Novel Gold Nanoparticles for Dipeptide Recognition in Water

  • This work introduces a promising concept for the preparation of new nano-sized receptors. Mixed monolayer protected gold nanoparticles (AuNPs) for low molecular weight compounds were prepared featuring functional groups on their surfaces. It has been shown that these AuNPs can engage in interactions with peptides in aqueous media. Quantitative binding information was obtained from DOSY-NMR titrations indicating that nanoparticles containing a combination of three orthogonal functional groups are more efficient in binding to dipeptides than mono or difunctionalised analogues. The strategy is highly modular and easily allows adapting the receptor selectivity to a given substrate by varying the type, number, and ratio of binding sites on the nanoparticle surface.

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Author:Serap Yapar
URN (permanent link):urn:nbn:de:hbz:386-kluedo-45041
Advisor:Stefan Kubik
Document Type:Doctoral Thesis
Language of publication:English
Publication Date:2016/12/06
Year of Publication:2016
Publishing Institute:Technische Universität Kaiserslautern
Granting Institute:Technische Universität Kaiserslautern
Acceptance Date of the Thesis:2016/09/13
Date of the Publication (Server):2016/12/12
GND-Keyword:Gold nanoparticles, recognition, water, dipeptide, DOSY
Number of page:IV, 136
Faculties / Organisational entities:Fachbereich Chemie
DDC-Cassification:5 Naturwissenschaften und Mathematik / 540 Chemie
Licence (German):Standard gemäß KLUEDO-Leitlinien vom 30.07.2015