TY  - INPR
A1  - Stinner, Christian
A1  - Surulescu, Christina
A1  - Uatay, Aydar
T1  - Global existence for a go-or-grow multiscale model for tumor invasion with therapy
N2  - We investigate a PDE-ODE system describing cancer cell invasion in a tissue network. The model is an extension of the multiscale setting in [28,40], by considering two subpopulations of tumor cells interacting mutually and with the surrounding tissue. According to the go-or-grow hypothesis, these subpopulations consist of moving and proliferating cells, respectively. The mathematical setting also accommodates the effects of some therapy approaches. We prove the global existence of weak solutions to this model and perform numerical simulations to illustrate its behavior for different therapy strategies.
KW  - tumor cell invasion
KW  - haptotaxis
KW  - asymptotic behavior
KW  - multiscale model
KW  - go-or-grow
KW  - delay
Y1  - 2016
UR  - https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/4294
UR  - https://nbn-resolving.org/urn:nbn:de:hbz:386-kluedo-42943
ER  -